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The considerable TSB of SBS-PolkKO mutations suggests that the endogenous lesions driving mutation in the absence of Pol are also repaired by a transcription-coupled mechanism

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Kim J, Gupta R, Blanco LP, Yang S, Shteinfer-Kuzmine A, Wang K, et al

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This results in impaired autophagosome-lysosome fusion, consequently activating downstream oncogenic signaling pathways such as RAS/RAF/MEK/ERK, which further drives the progression of cirrhosis-associated HCC (149)

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doi: 10.1007/3-211-30714-1_38

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