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These isoenzymes are principally responsible for 95% of all detoxification of drugs, with CYP3A4 being responsible for detoxification of roughly 50% of drugs

Neuropsychopharmacology 37:163177

Incidence and risk factors of clinically significant chemotherapy-induced thrombocytopenia in patients with solid tumors

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253,269 One observational study that followed 64 participants with biopsy-confirmed NASH for five years after bariatric surgery found that 84% had resolution of NASH, 70.2% had decreased fibrosis, and 56% had disappearance of fibrosis