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Strikingly, unlike bacterial lipopolysaccharides, BDG induced intracellular glutathione synthesis

Nevertheless, the persistence of an imbalance favouring high oestradiol and low progesterone levels, as frequently observed during perimenopause (lasting approximately 69 years) 20,21,22,23,24 , has been linked to heightened susceptibility to seizures 25 , stroke 26 and binge drinking 27 conditions recognised as risk factors for Alzheimers disease and Alzheimers disease-related dementias (AD/ADRD) 28,29,30

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In some cases, sparing the LN and exploring alternative treatment strategies may be a practical option

Di Monte et al