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By forming a complex with bile acids that cannot be absorbed by the body, cholestyramine prevents recycling of bile acid through the process of enterohepatic recirculation

And the exercise interaction backs this up: higher fitness builds a greater parasympathetic reserve (essentially, a better ability to slow your heart rate), which helps offset the sympathetic drive from GLP-1

These treatments have proven highly effective for people struggling to lose weight through diet and exercise alone.

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Supervised personal training for adults over 40 on GLP-1 medications in Palm Springs