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Svendahl L, Underwood LE: Fasting increases serum total cholesterol, LDL cholesterol, and apolipoprotein B in healthy, nonobese humans

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Pathology of Thiamine Deficiency As indicated above, the pathology of thiamine deficiency entails impaired energy-production from mitochondria in the form of ATP when using pyruvate-generating substrates (e.g., glucose) as well as increased oxidative stress ( via glycolysis generates pyruvate, which cannot enter the Krebs cycle as acetyl-CoA due to the low activity of PDH

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