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Intracellular glutamine, in synergy with the transporters SLC1A5 and SLC7A5/3A2, can assist leucine entry into cells, thereby promoting mTORC1 activation and inhibiting autophagy [81]

The path forward Future research should prioritize largescale, biomarkerguided clinical trials of wellcharacterized polyphenols (curcumin, EGCG, resveratrol) administered in nanoformulated or liposomal forms to overcome bioavailability barriers

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