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In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

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Skipping of exon 14 removes Y1003, a key phosphorylation site required for CBL-mediated c-MET ubiquitination and subsequent degradation, resulting in aberrant c-MET accumulation and prolonged signaling, thereby driving unchecked cellular proliferation [45,46,47,48]

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Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

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[13] Because cagrilintide retains intrinsic calcitonin-receptor agonism alongside amylin-receptor activity, it is most accurately described as a dual amylin/calcitonin receptor agonist rather than a pure amylin analog

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Complications after laparoscopic umbilical hernia surgery are uncommon

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After euthanasia, the pancreas was perfused via the common bile duct with 24 mL of digestion buffer (Hanks Balanced Salt Solution containing type IV collagenase, 1 mg/mL, Gibco, 17104019)

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