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Notably, the Jaccard distance between the PMA+ samples from the Glut group and those from the THPS group was 0.51 (Fig

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Recombinant Erwinia asparaginase (JZP458) in acute lymphoblastic leukemia: results from the phase 2/3 AALL1931 study
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It is also appealing for additional chemical alterations, since its structure provides an intriguing framework (with multiple reactive sites) for drug discovery

However, drugs or nanoparticles targeting the transferrin receptor (TfR) face clinical translation hurdles due to peripheral tissue sinks, reticulocyte depletion, and lysosomal entrapment issues [126,127,128,129]
