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Its the silent variable that can make or break your findings

Unlike the results found in previous studies, the effect of high dose N -acetylcysteine on air trapping and airway resistance of chronic obstructive pulmonary disease, a double-blinded, randomized, placebo-controlled trial (HIACE) conducted with 120 patients with stable COPD (58 treated with 600 mg of oral NAC twice a day and 62 with placebo), demonstrated a significant improvement in the function of the small airways, in addition to a reduction in the frequency of exacerbation of the disease [53]

It has various repercussions on the quality of life of the affected individuals, ranging from being slightly bothersome to highly incapacitating with sleep disturbances, anxiety, and depression [2]

ALA activates the Nrf2 pathway, downregulating the NF-B inflammatory cascade in macrophages and clearing reactive oxygen species from the newly formed mitochondria