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doi: 10.1093/pcp/pch008 54 OtulakK.GarbaczewskaG

The phenotypes are not correlated with microenvironmental features, including proliferation rate, immune cell infiltration and vascularization, are retained when patient-derived cells are grown in vitro or as orthotopically implanted xenografts and are robust to changes in oxygen concentration, demonstrating their cell-intrinsic nature

ROS, in turn, are often potent chemical messengers that trigger cellular stress responses (Choudhury et al

The study will evaluate oxidative stress markers and intestinal barrier function to understand the impact of HT on intestinal oxidative stress