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This also results in the formation of advanced glycosylation end products (AGEs), which are modifications of proteins or lipids that become non-enzymatically glycosylated when exposed to aldose sugars and oxidative stress (213-215)

It was also previously shown the core clock genes including per , tim , and Pdp1 have a significant regulatory effect on circadian rhythm activity in Drosophila (Wang et al, 2001

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Epigenetic regulation: The epitranscriptional factor PCIF1 modulates m6Am modification, influencing ferroptosis-suppressing genes and the expression of CD8 + T cell activation markers (CD69)

Kavusak, S