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What is the most appropriate dose of N-acetylcysteine after a massive acetaminophen overdose

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Results previously published concluded that mitochondria of true endotherms (such as birds and mammals) produce lower rates of ROS generation compared to fish and showed higher levels of antioxidant enzymes compared to fish [24]
This powerful tripeptide of cysteine, glycine, and glutamic acid neutralizes harmful free radicals, supports detoxification, and strengthens the immune system

For the symptomatic management of vomiting, diphenhydramine may be given intramuscularly or intravenously at a dose of 1 mg/kg, not exceeding 50 mg per dose (Arroabarren et al