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HFpEF exhibits more complexity and has more associated-comorbidities including hypertension compared to HFrEF, and systemic inflammation and its-induced metabolic injury are closely associated with the pathogenesis of HFpEF

While a moderate concentration of ROS is critical for eggsperm fusion, and fertilization, excessive ROS generation is primarily related to telomere shortening, sperm DNA fragmentation, and alterations in the methylation pattern leading to male infertility

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HFD feeding induces high AST, ALT, T-CHO, and LDL-C levels and increases liver weight AST, ALT, T-CHO, and LDL-C levels increased with age in both sexes in all the HFD-treated groups

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