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Last updated 6/18/2012

doi: 10.3389/fendo.2025.1762825 Received 08 December 2025 Revised 30 December 2025 Accepted 31 December 2025 Published 06 February 2026 Volume 16 - 2025 Edited by Antoni Sureda, University of the Balearic Islands, Spain Reviewed by Elisa Dietrich, Sapienza University of Rome, Italy Lara Russo, National Research Council (CNR), Italy Updates Copyright 2026 Yu, Ge, Fu and Zhao

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4547 There is an ongoing open-label clinical trial in adults with late-onset OTCD (ClinicalTrials.gov Identifier: NCT02991144)

Despite this evidence, acetyl-l-carnitine is currently not approved as a drug for any indication in the United States

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