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The highly abiotic stress responsive genes of the present study such as CaGSTF 3, CaGSTL 2, CaGSTL 3, CaEF1B 1, and CaGSTU 44, showed the presence of a variable amount of HSE, MBS, TC-rich repeat, and LTR motifs (Figs 6, 7)

P., Van Pelt, J

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Lactate also acts on these immune cells epigenetically by increasing H3K9 acetylation in macrophages at genes like ARG1 and Retnla, reinforcing M2 gene expression and locking TAMs into an M2 polarized state (61)

Most patients see meaningful improvement within two to four months, with maximum benefit typically reached by month six

Ethics statement The animal studies were conducted in accordance with the recommendations of the European Community (Directive 2010/63/EU, 1 January 2013)