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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES

Nat Commun 8 , 15868 (2017)

In their 2014 lung cancer study they also found that antioxidant supplements caused lung tumor cells to turn off the activity of a well-known cancer-suppressing gene called p53

However, fuller recovery tends to develop gradually over several months, depending on individual healing capacity and symptom severity

Townsend CM, Parker CE, MacDonald JK, Nguyen TM, Jairath V, Feagan BG, Khanna R

Mitochondria can control the intracellular intake of iron, influencing its availability, which plays a crucial role in ferroptosis