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As for targeted therapy in cancer metabolism, gain of function mutations in isocitrate dehydrogenases (IDH1 and IDH2) result in the production of the oncometabolite 2-hydroxyglutarate (140, 141)

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Alternatively, cells can be used for protein determination or other metabolite measurements

Vitamin B12, also known as cobalamin, is a crucial water-soluble vitamin that plays an essential role in red blood cell formation, nerve function, and DNA synthesis

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In contrast to LCTs that enter host cells as single polypeptides, binary toxins are secreted by the bacterium as two separate components A and B, and enter cells after binding component B to their receptors [73,199]