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Autocrine/paracrine GH acts in pituitary cells as an apoptosis switch for p53-mediated senescence, likely preventing the pituitary adenoma cells from progression to malignancy [100]

& Vinken, M

The selective inhibition of HDAC6 offers a way to modulate its activity in disease without affecting the global acetylation levels that could result from broadly inhibiting HDACs

Though mitochondrial metabolism is implicated in ferroptosis, mitochondrial function is reported to progressively decline upon prolonged cysteine deprivation, marked by drastic changes in membrane potential, damage to the IMM, and fragmentation of the mitochondrial network in fibrosarcoma, breast, and liver cancers 15,22,61

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Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits
