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Patients with vitiligo experience depigmentation due to the autoimmune attack of melanocytes by T cells, resulting in the formation of white patches on the skin

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This coordination reduces hepatic exposure to gut-derived inflammatory stimuli while simultaneously alleviating metabolic and immune stress through improved microbial homeostasis, intestinal barrier function, and host signaling regulation

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The 57 CYP genes identified from the human genome project gave new insight into the extent of CYP isoforms, with many of these enzymes covering a large range of functions, although the role of some isoforms remains unknown (Ingelmansundberg, 2005)