parkinson's glutathione perlmutter Astrocytes Role in Parkinson: A Double-Edged Sword Small Molecules, α-Synuclein Pathology, and

Trends Cancer 4 , 662670 (2018)

This high-activity conformation is particularly important in rapidly proliferating cells

Vitamin E, a lipid-soluble antioxidant, protects cell membranes from lipid peroxidation [42], while vitamin C, a water-soluble antioxidant, can regenerate vitamin E from its oxidized form and scavenge various ROS [43]

A key mechanism for GSH's role in DNA synthesis relates to the maintenance of reduced glutaredoxin or thioredoxin, which is required for the activity of ribonucleotide reductase, the rate-limiting enzyme in DNA synthesis [32]

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[PubMed] [Elsevier] Maher TJ, Glaeser BS, Wurtman RJ