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Limitations of this study include a small sample population of healthy older adults with high BMI in order to ensure safety

Subcutaneous administration produces the longest clearance time at around 2.53 hours, while intraperitoneal routes show faster elimination at one to two hours

In the altered scenario of cholestasis, the retention of more hydrophobic bile salts, such as the glyco- and tauro-conjugates of deoxycholate, plays a major part in the onset of liver injury, causing hepatotoxicity due to mitochondrial dysfunction and production of ROS, with consequent oxidative damage [181,182]

The aim is to avoid re-injury by carefully controlling the stress placed on the tendon

Changes in blood plasma in response to GlyNAC supplementation were not significant, although the medium dose showed a trend towards improved glycine status (4.8 g, p -value = 0.068) (Supplementary Figure S5)