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Biguanides A double-blinded randomized controlled trial (RCT) assessing the efficacy of metformin in the prevention of PIPN showed that the development of grade two or more peripheral neuropathy (PN) was significantly lower in the metformin group compared to placebo ( p = 0.001)
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10.3390/ijms20061451 225 ZhangS
Karagas, M
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