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Hu W, He C, Fang B, Swisher SG

Supernatants were transferred into new tubes and pellets discarded

These may include pollution, chemicals, and compounds found in processed foods

Can other NADPH producing pathways, such as IDH1 and ME1, be targeted to compensate for G6PD deficiency in chronic diseases or in a hemolytic context

In recent years, many key molecular mechanisms of ferroptosis have been identified, including GPX4-GSH, ferroptosis-suppressor-protein 1 (FSP1)-CoQ 10 , GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH 4 ), dihydroorotate dehydrogenase (DHODH)-CoQ, and FSP1-vitamin K (VK)[8, 17-19] (Figure 1)