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They are successfully used for the treatment of childhood epilepsies, where several controlled clinical trials have now shown efficacy (Martin et al., 2016) and there is also some efficacy against seizures in adults

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Percyquinin Percyquinin obtained from the cultures of Basidiomycetes Stereum complicatum ST 001837 [101], inhibited PL with an IC50 of 2 mm, is another -lactone metabolite

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Regarding the type of AEs, 18 patients (13.1%) reported insomnia, 15 patients (10.9%) reported widespread shivering, 10 patients (7.3%) reported headache, and 5 patients (3.6%) reported nausea (Table 3)