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The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction with tirzepatide 15mg weekly at 72 weeks, while preclinical 5-amino-1MQ studies showed visceral fat reduction independent of caloric restriction

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ATP binding to the c-Met, inhibiting receptor transactivation and recruitment of the downstream effectors can be achieved also by low molecular weight inhibitors SU11274 and PHA-665752