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Dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the pyrimidine de novo synthesis pathway, works alongside GPX4 to inhibit mitochondrial lipid peroxidation

doi:10.3233/JAD-150140

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Volpert HM, PfeiffenbergerJ, Groner JB, Stremmel W, Gotthardt DN, Schafer M, et al