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More important than how much weight is lost, Drucker told CNN Friday, are the health benefits GLP-1 medicines have shown in studies, which include reduction of metabolic liver disease and sleep apnea and osteoarthritis and heart disease and strokes, which dont appear to be strictly weight-loss dependent. Even if next-generation medicines show greater degrees of weight loss, Drucker said, it takes several years for trials to prove benefits on other outcomes like those, which may be more meaningful to patients and doctors

A four-week hold is roughly the window needed for a step to reach steady state and for the gut to adapt to it, which is why escalating before the block is complete effectively means judging a dose you have not yet fully experienced