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The potential bias in the treatment comparisons was mitigated by the matched double-blind placebo controls, but this could have been further improved with a double-dummy approach

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In rats, liraglutide decreases food intake when directly injected into the ARC, LHA, or PVN while direct administration into the VMH decreases body weight without affecting food intake, but increases the expression of Ucp1 in the brown and inguinal white adipose tissue [666]