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Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

A recent study also indicated that the serum NNMT, L-Plastin (LCP1), non-metastatic cells 1 protein (NM23A) triple marker assay could be a powerful diagnostic assay for the early detection of renal cell carcinoma [125]

One study investigating these effects in obese mice discovered that administration of an NNMT blocker reduced insulin serum levels by 50-60% in the subjects