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Pioneering work by Macia et al

During GLP-1 infusion, urine was collected at 10, 20 and 30 min

Because SUMO expression is increased in mouse islets exposed to high glucose (Rajan et al., 2012), its interaction with GLP-1R may in part contribute to the reduced efficacy of incretin therapies in some T2DM patients with poorly controlled hyperglycemia (Fritsche et al., 2000

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GLP-1 possesses unique properties, including glucose-dependent insulin secretion, which confer a broad therapeutic index and reduce the risk of hypoglycemia