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Metformin, a primary antidiabetic drug for T2DM, is excreted unchanged in the urine and has been shown in several clinical studies, including the United Kingdom Prospective Diabetes Study, to reduce all-cause mortality and slow ESRD progression in patients with T2DM and DKD 5,6,32,33

10.1016/j.jhep.2008.04.026 J Hepatol

Protective efficacy and mechanism of gypenosides against diabetic cataracts via the ferroptosis pathway: A study based on network pharmacology

It would also mitigate radiation and low-gravity side effects, potentially reducing neurobehavioural effects such as boredom, loneliness, and aggression

Some of these risk factors can be treated naturally with natural remedies like exercise and acupuncture

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