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Indicators that the medication is working include reduced appetite and hunger, feeling satisfied with smaller portions, fewer food cravings, decreased mental preoccupation with food, and eventually progressive weight loss

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Practical Examples That Clarify Choices If you increase the dose, assume a new steady state will take weeks to stabilize, so symptom shifts after an escalation will lag

Since retatrutide is still being investigated, we do not know about its long-term risks