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doi: 10.3390/metabo13050587

Some people titrate slowly, tolerate the low doses well, but never experience meaningful appetite suppression or weight loss until they reach standard therapeutic doses anyway

Both Contrave and Wegovy are only available as brand-name drugs, which typically cost more than generics

Despite concerns about heart rate elevation, extensive cardiovascular outcome trials have demonstrated that GLP-1 receptor agonists are not only safe but may offer cardiovascular benefits for many patients

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These trials are critical because they provide the final data needed for regulatory review. MNT spoke with Jeffrey Kraft, MD, chief of general surgery, specializing in bariatric surgery, for Palisades Medical Center in New Jersey, about this study, who commented that his initial reaction to the results was one of measured optimism