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Description
Clinical trials Retatrutide clinical trials Retatrutide is investigational
Particularly, it determined the upregulation of ROS-scavenging enzymes, anti-inflammatory cytokines, (IL-10, IL-6 and PPAR ), tight junctions proteins, such as ZO-1, MUC-2, claudin-3, and the downregulation of inflammatory genes (TNF-, IL-1) [14]

The 200%+ GLP-1 increase figure comes from the average of both studies combined

The addition of glucagon receptor agonism is what distinguishes retatrutide from tirzepatide and is the key driver of its superior efficacy

doi:10.1016/j.jchf.2023.05.010 3

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