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Nevertheless, despite increased levels of GLP-1, TG excursion was not reduced, and was actually transiently increased, in HFD-fed mice after gut-selective sitagliptin (Figure 5B)

Normally, advice is to swap white, starchy carbohydrates for high-fibre, brown complex carbohydrates to manage appetite regulation, promote gut health and manage energy levels

Additionally, there are important concerns regarding long-term safety

16.1% on semaglutide Tirzepatide was superior on all five key secondary endpoints Gastrointestinal discontinuation rate was lower with tirzepatide (2.7%) than semaglutide (5.6%) These findings were consistent across all patient subgroups, regardless of sex, age, baseline BMI, or presence of metabolic comorbidities

The minutes and hours after injection matter more than most people realize

Glucagon like peptide 1 receptor agonists in the treatment of obesity
