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However, once the benzimidazole is detached from cobalt by quaternization with methyl iodide, it is replaced by H 2 O or hydroxyl ions

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These results suggest that the putatively vesicular copper released from neurons following NMDAR stimulation (Schlief et al., 2005) may act on NMDARs themselves to rein in excessive excitation, and that additional copper release can protect neurons from excitotoxic cell death

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Chang AB, Marchant JM