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They may be prescribed when commercially available products are unsuitable for an individuals medical needs, but have not been evaluated by the FDA to confirm safety or efficacy for any specific use

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Certifications of Analysis (CoA) which validate each of these metrics are readily available upon request

Contribution statement All authors contributed to the conception and design of this review, drafting of the article, revising for critically important content and approved the final version to be published

There are two main reasons