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Waist circumference is an independent predictor of metabolic risk

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The National Institute for Health and Care Excellence (NICE) recommends that healthcare professionals discuss common adverse effects before initiating GLP-1 receptor agonist therapy

For those with symptoms despite the above first-line medications, second-line therapies include the addition of disopyramide or the newer myosin inhibitors (e.g., mavacamten)

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This approach addresses both affordability and individual variabilitytwo factors that branded fixed-dose medications alone cannot optimize