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While metformin remains the first-line treatment for T2D, GLP-1s may be used in combination with metformin for additional benefits

The missed dose window is three days, shorter than both semaglutide and tirzepatide

2017, Frias et al

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It can run in opposite directions on the same person

Mol Metab 46:101090 Miyake T, Yoshida O, Matsuura B et al (2022) additional effect of luseogliflozin on semaglutide in nonalcoholic steatohepatitis complicated by type 2 diabetes mellitus: an open-label, randomized, parallel-group study