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Even if Thrive doubles your natural GLP-1 production, you still only have twice the amount of a hormone that disappears within minutes

Precautions and Safety Sterility and Single Use: Each insulin syringe and needle should be used only once

But the FDA would like more general heart data for weight-loss drugs, Sharretts says

How Long Fatigue Typically Lasts During Treatment Fatigue is most pronounced during dose escalation and commonly begins to improve once the dose stabilises, though retatrutide-specific week-by-week timeline data remain limited from published Phase 2 trial results
These errors can lead to unintended consequences, including severe side effects or ineffective treatment

According to SELF , her experience is an outlier
