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Newer alternative treatments for sickle cell anemia include crizanlizumab (Adakveo) which is a monoclonal antibody therapy

12 , 13 Moderate physical activity and healthy diets promote a balanced microbiome (eg, a high Bacteroidetes to Firmicutes ratio) along with the production of neurotransmitters (eg, serotonin, dopamine), secondary bile acids, and short-chain fatty acids, including acetate, propionate, and butyrate (Figure 1)

June 14 2022: Researchers compared the adverse effects experienced by patients who took Pfizer or Moderna's mRNA vaccine over the course of 42 weeks

Biomed Res Int 2015

It can also be the sign of more complicated disorders of the blood cells (but always look at the obvious know problems first -IBS, absorption issues etc)

Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, et al