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Remember that very tight glucose control in early pregnancy is critical for reducing birth defect risk

Pharmacokinetics: Bioavailability: ~90% Half-life: ~2430 hours Metabolism: Minimal hepatic metabolism Excretion: Mainly renal Adverse Effects: Headache Nausea Abdominal pain Diarrhea Interesting Fact: Unlike older prokinetic agents (like cisapride), prucalopride has high receptor selectivity, reducing the risk of cardiac arrhythmias a major safety improvement

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When comparing diarrhea rates, always consider the weight loss achieved

A doctor can help you leverage this effect to break bad habits permanently

More RCTs are needed to assess the cardiovascular benefits of GLP-1 RAs in HF, regardless of T2DM