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Small heat shock protein activity is regulated by variable oligomeric substructure

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[DOI] [PubMed] [Google Scholar] 32.Bazzoni G

Reduced fast axonal transport can cause degeneration in distal parts of the axons as observed in X-linked spastic paraplegia type 2, which is caused by a mutation of the PLP1 gene, a major protein of the myelin sheath

It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]

Besides, the intrinsic reactivity of GSS in comparison with GS is increased 1.8-fold with peroxynitrite, and 44-fold with monobromobimane