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For people with complex medical needs such as type 2 diabetes, kidney disease, gastrointestinal conditions or a history of bariatric surgery working with an APD is even more important

Patients with pre-existing cardiovascular disease face elevated risks

However, for some individuals, side effects could lead to gastrointestinal issues such as constipation, diarrhea, and nausea

Salinas et al., 2018)

Phase 3 clinical trials indicate that people lost 28.3% of their body weight after 80 weeks on 12 mg of retatrutide, with 45% losing 30% or more of their weight

Women reported nausea at 31 percent compared to 24 percent for men at the 12mg dose