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Maybe we'll be using them for substance use and addiction related disorders, and peripheral artery disease, and metabolic liver disease, and Alzheimer's disease, and all kinds of arthritis and inflammatory conditions and maybe their utility [will] be far greater than we ever imagined. Key points GLP-1 peptides discovered by Joel Habener and colleagues laid the groundwork for modern type 2 diabetes drugs

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Specific role for acyl CoA: Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids

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They support weight loss not by stimulating the body, but by reinforcing the hormonal signals that help regulate appetite and glucose balance