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The co-primary endpoints, percent change in body weight from baseline and proportion of patients achieving 5% weight loss, were identical to those of SURMOUNT-1, as were the two estimands: the TRE (which included all patients who were randomized) and the efficacy estimand (which included randomized patients who remained on the study treatment for the entire efficacy assessment duration of the trial)

Handling and storage should follow institutional laboratory protocols to maintain stability, purity, and analytical integrity

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Before starting either medication, your provider will review your personal and family history of thyroid cancer, pancreatitis, gallbladder disease, kidney function, and pregnancy plans

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There isnt enough data to know for sure, but because of potential risks, doctors recommend avoiding tirzepatide if you are pregnant or planning pregnancy