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Studies have shown that hyperglycemia-induced mitochondrial fragmentation, mediated by an imbalance in fission and fusion proteins such as Drp1 and OPA1, contributes to mitochondrial dysfunction and impairs ATP synthesis in retinal capillary and Mller cells (16)

As a result, ROS production increases, activating antioxidant responses [95, 226, 227]

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PMID 33328986