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Patients with significant symptoms that do not improve concurrently with the physical symptomatology need clinical and psychological support both at home and at work

Cunha, L., Bonfim, L., Lima, G., Silva, R., Silva, L., Lima, P., Oliveira-Bahia, V., Freitas, J., Burbano, R., & Rocha, C

Organ-specific toxicity is another critical area of concern

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This was due to the presence of autoantibodies against folate receptor which blocked the folate binding site

These reactive compounds interact with amino groups (NH 2 ) in proteins and DNA bases, leading to the formation of adducts that can cause mutations (Yang et al., 2019)