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Summary Integrating emerging mechanistic and clinical observations, this review synthesizes current evidence from a metabolic flux perspective

Bone 154:116236 [DOI] [PubMed] [Google Scholar] 36.Paccou J, Thuillier D, Courtalin M, Pigny P, Labreuche J, Cortet B, Pattou F (2022) A comparison of changes in bone turnover markers after gastric bypass and sleeve gastrectomy, and their association with markers of interest

Unimolecular peptides with dual GIP/GLP-1 receptor agonism have been developed to improve metabolic efficacy and therapeutic index beyond what incretin mono-agonists can achieve (44, 63)

These drugs have proven effective in managing chronic illnesses such as type 2 diabetes (T2D) and obesity, enhancing glycemic control, promoting weight loss, and reducing cardiovascular issues [12]

Insulin is the most critical because a person can die quickly without it
