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Statistical analysis GraphPad Prism v8 was employed for statistical tests

This indicates a necessity for the development of therapeutics to inhibit the process
Dimethyl fumarate in the treatment of relapsingremitting multiple sclerosis: an overview

10.1016/j.addr.2023.114895 202 WestdorpH.SkldA

Mutations at Tyr55 did not completely impair the enzyme activity, but the Tyr55 mutant AtPCS1 showed lower catalytic activities than the wild-type enzyme due to a reduced affinity to metal-GS 2

Once folic acid is a precursor in de novo synthesis of thymidine, MTX imbalances nucleotide pools, ultimately leading to incorrect DNA synthesis and halting cell division
